Systems of partial differential equations are really complicated beasts: in contrast to systems of ordinary differential equations, they are not equivalent to a single PDE of higher order, cf. the discussion in Courant/Hilbert `Methoden der Mathematischen Physik'.
Related problems occur in the theory of the Laser, where one has to deal with PDEs containing derivatives up to infinite order. This is discussed in the book by Scully/Lamb. Another, very recent challenge are systems of Master equations with non-linear couplings between bosonic and electronic degrees of freedom in nano-electromechanical systems.